Pretty sure they don't share a connection. I have 2 sets of headphone sockets. One is on the back near the top and is hardwired to the motherboard. The one I'm using now is on the front of the PC on a box with headphone, mic and 2 USB 2 sockets.
The mouse is plugged into a rear 4x USB 2 PCI card.
So I can't see any way they could be interfering directly...
i5 4440 3.1Ghz, Asus H87M-E motherboard, 8GB DDR3, 2GB DDR5 nVidia card, 2x500GB Seagate hd, Coolermaster 750W PSU running Mint 16 MATE and Win7
eeepc 1015PX, 1.66 Ghz Intel atom processor, 2 GB DDR3, 320 GB hd, Mint 14 MATE. Fan needs fixing.